S84674 |
UK-371804 |
| 源叶(MedMol) | 98% |
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- 产品描述： UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.
- 靶点： Ki: 10 nM (uPA)
- 体外研究： UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 μM). UK-371804 has its excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin)
- 体内研究： In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM
- 参考文献：
1. Fish PV, et al. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51.
- 溶解性： Soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.592 ml 12.959 ml 25.918 ml 5 mM 0.518 ml 2.592 ml 5.184 ml 10 mM 0.259 ml 1.296 ml 2.592 ml 50 mM 0.052 ml 0.259 ml 0.518 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
