货号	规格	价格	上海	北京	武汉	南京
S84720-5mg	≥97%	￥430.00 S84720-5mg ￥430.00 现货	10 10	-	-	-
S84720-10mg	≥97%	￥630.00 S84720-10mg ￥630.00 现货	7 7	-	-	-
S84720-25mg	≥97%	￥1000.00 S84720-25mg ￥1000.00 现货	4 4	-	-	-
S84720-50mg	≥97%	￥1470.00 S84720-50mg ￥1470.00 2-3天	0 货期：2-3天	-	-	-
S84720-100mg	≥97%	￥2200.00 S84720-100mg ￥2200.00 2-3天	0 货期：2-3天	-	-	-

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产品描述：

SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α

靶点：

IC50: 110 nM (p38 MAPK);p38MAPK;Autophagy

体外研究：

SD 0006 clearly inhibits p38α as shown by the dose-dependent inhibition of phosphorylation of its endogenous Hsp27 substrate

体内研究：

SD 0006 (0-30 mg/kg) may be an effective alternative to steroids and biologics for RA therapy. SD0006 (3.75, 7.5 and 15 mg/kg; p.o.; b.i.d.) is highly effective in attenuating SCW-induced inflammation as shown by the dose-dependent inhibition of paw swelling. Animal Model: 8- to 12-week-old DBA/1 mice. Dosage: 3.75, 7.5 and 15 mg/kg. Administration: Orally twice daily. Result: Inhibited the transcription of several inflammatory mediators to prevent joint swelling and bone destruction and to preserve bone density.

参考文献：

1. Burnette BL, et al. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84(1):42-60. 2. Walker JK, et al. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.513 ml	12.567 ml	25.135 ml
5 mM	0.503 ml	2.513 ml	5.027 ml
10 mM	0.251 ml	1.257 ml	2.513 ml
50 mM	0.05 ml	0.251 ml	0.503 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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