| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S84887-2mg一口价 |
99.90% | ￥140.00 | 5 | - | - | - |
|
S84887-5mg一口价 |
99.90% | ￥224.00 | 6 | - | - | - |
|
S84887-10mg一口价 |
99.90% | ￥336.00 | 6 | - | - | - |
|
S84887-25mg一口价 |
99.90% | ￥536.00 | 5 | - | - | - |
|
S84887-50mg |
99.90% | ￥1000.00 | 5 | - | - | - |
|
S84887-100mg |
≥99% | ￥1500.00 | 货期：2-3天 | - | - | - |
|
| 产品描述： | JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 30 nM (Hedgehog);Hedgehog/Smoothened | ||||||||||||||||||||
| 体内研究： | JK184 (5 mg/kg, injected intravenously) exhibits good anti-proliferative activity in subcutaneous Panc-1 and BxPC-3 tumor models, and is a good candidate as antitumor drug targeted Hh signaling. However, JK184 has a poor pharmacokinetic profile and bioavailability | ||||||||||||||||||||
| 参考文献： | 1. Zhang N, et al. Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway. Nanoscale. 2015 Feb 14;7(6):2609-24. 2. Colavito SA, et al. Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway. Breast Cancer Res. 2014 Sep 25;16 | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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