货号	规格	价格	上海	北京	珠海	武汉
S85331-1mg	99.60%	￥265.00 S85331-1mg ￥265.00 现货	8 8	-	-	-
S85331-5mg	99.60%	￥560.00 S85331-5mg ￥560.00 现货	9 9	-	-	-
S85331-10mg	99.60%	￥976.00 S85331-10mg ￥976.00 现货	8 8	-	-	-
S85331-50mg	99.60%	￥3060.00 S85331-50mg ￥3060.00 现货	7 7	-	-	-
S85331-100mg	99.60%	￥5780.00 S85331-100mg ￥5780.00 现货	5 5	-	-	-

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产品描述：

RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells

靶点：

IC50: 5-30 μM (RAD51);DNA/RNASynthesis

体外研究：

RI-1 (1-50 µM; 24 h) specifically inhibits homologous recombination (HR) in U2OS cells and stimulates single-strand annealing (SSA) in HEK293 cells. RI-1 (5-20 µM; 30 min) inhibits HsRAD51 in a concentration-dependent manner. RI-1 (20 µM; 8 h) disrupts the formation of RAD51 foci after DNA damage in immortalized human fibroblasts. RI-1 (15-25 µM; 24 h) sensitizes human cancer cells (HeLa, MCF-7 and U2OS) to cross-linking chemotherapy

体内研究：

RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice. Animal Model: Female BALB/c nude mice (6 weeks) bearing TNBC tumor Dosage: 50 mg/kg Administration: I.p. every 3 days for 30 days Result: Resulted in significant inhibition of tumor growth.Did not cause body weight loss significantly.

参考文献：

1. Budke B, et, al. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 Aug;40(15):7347-57. 2. Shi Y, et, al. DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors. Neoplasia. 2019 Jun;21(6):533-544.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.765 ml	13.827 ml	27.654 ml
5 mM	0.553 ml	2.765 ml	5.531 ml
10 mM	0.277 ml	1.383 ml	2.765 ml
50 mM	0.055 ml	0.277 ml	0.553 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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