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• 产品描述： Eribulin Mesylate (E7389, B-1939, ER-086526,E7389 mesylate) 是海洋天然产物软海绵素 B 的类似物，是一种非紫杉烷完全合成的 微管 (microtubule)抑制剂

• 靶点： microtubule

• 体外研究： Eribulin Mesylate (1-100 nM; 72 h) inhibits cells proliferation of LM8 and Dunn cells. Eribulin Mesylate (10-50 nM; 12-72 h) increases early apoptosis significantly in LM8 cells. Eribulin Mesylate (10-50 nM; 12-72 h) induces G2/M arrest by 12 h treatment with at the dose of 50 nM, but not by long-term treatment (72 h) with 10 nM in LM8 cells. Eribulin Mesylate (1-10 nM; 16 h) induces morphological change and suppresses cell migration in a low concentration in LM8 cells

• 体内研究： Eribulin Mesylate reduces primary tumor growth and lung metastasis of osteosarcoma in mice

• 细胞实验： Cell lines: LM8 cells, Dunn cells Concentrations: 10 nM, 50 nM Incubation Time: 72 h Method: LM8 cells and Dunn cells are incubated with 0 nM, 10 nM, or 50 nM eribulin Mesylate for 12 h, 24 h, 48 h, or 72 h. And then cell proliferation, cell cycle and apoptosis are detected by flow cytometry analysis and immunofluorescence.

• 动物实验： Animal Models: 4-week-old C3H/HeN mice inoculated with LM8 cells Dosages: 1 mg/kg Administration: I.v.

• 参考文献：
  1. Sarika Jain, Linda T Vahdat. Eribulin mesylate. Clin Cancer Res. 2011 Nov 1;17(21):6615-22. 2. Watanabe K, et al. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4;10(2):161-174.

• 溶解性： 10  mM  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	1.211 ml	6.053 ml	12.107 ml
  5 mM	0.242 ml	1.211 ml	2.421 ml
  10 mM	0.121 ml	0.605 ml	1.211 ml
  50 mM	0.024 ml	0.121 ml	0.242 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *