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Lersivirine

    
≥98%

Lersivirine

源叶(MedMol)
S85485 一键复制产品信息
473921-12-9
C17H18N4O2
310.35
货号 规格 价格 上海 北京 武汉 南京 购买数量
S85485-1mg
≥98% ¥150.00 10 - - -
S85485-5mg
≥98% ¥255.00 7 - - -
S85485-10mg
≥98% ¥500.00 5 - - -
S85485-25mg
≥98% ¥860.00 4 - - -
S85485-50mg
≥98% ¥1470.00 货期:2-3天 - - -
S85485-100mg
≥98% ¥2390.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: Lersivirine (UK-453061) is potent and selective non-nucleoside reverse transcription inhibitor (NNRTI; IC50=119 nM) with excellent efficacy against NNRTI-resistant viruses. Lersivirine exhibits potent antiretroviral activity against wild-type HIV virus and clinically relevant NNRTI-resistant strains
靶点: IC50: 119 nM (NNRT);HIVProtease;ReverseTranscriptase
体内研究: Lersivirine (oral gavage; 0, 150, 350, and 500 mg/kg; once daily; gestation days 6 to 17, followed by cesarean section on gestation day 18. ) allows induction of hepatic metabolizing enzymes at the first 2 days at 250 mg/kg, after which the dose is increased to 500 mg/kg/day in Mated Crl:CD1(ICR) mice. Lersivirine leads to skeletal variations which related to delayed development and decreased fetal ossifications
参考文献: 1. Mowbray CE, et al. Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5857-60. 2. Gregg D Cappon, et al. Developmental toxicity study of lersivirine in mice. Birth Defects Res B Dev Reprod Toxicol. 2012 Jun;95(3):225-30.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.222 ml 16.111 ml 32.222 ml
5 mM 0.644 ml 3.222 ml 6.444 ml
10 mM 0.322 ml 1.611 ml 3.222 ml
50 mM 0.064 ml 0.322 ml 0.644 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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