S85811 |
Etifoxine Hydrochloride |
| 源叶(MedMol) | 99% |
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- 产品描述： Etifoxine hydrochloride, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine hydrochloride reveals anxiolytic and anticonvulsant properties in rodents
- 靶点： GABA Receptor
- 体内研究： Etifoxine competitively inhibits [35S]TBPS binding with micromolar potency in rat brain. Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice Animal Model: Six-week old BALB/cByJ and C57BL/6J mice (20-25 g). Dosage: 3.125-50 mg/kg. Administration: Intraperitoneal inhection. Result: Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice.BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower plasma levels of the compound at 15 and 30 min.
- 参考文献：
1. Marc Verleye, et al. Effects of etifoxine on ligand binding to GABA(A) receptors in rodents. Neurosci Res. 2002 Oct;44(2):167-72. 2. Alain Hamon, et al. The modulatory effects of the anxiolytic etifoxine on GABA(A) receptors are mediated by the beta subunit. Neuropharmacology. 2003 Sep;45(3):293-303. 3. Marc Verleye, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;21(6):457-70.
- 溶解性： Soluble in DMSO、H2O
- 保存条件： -20°C
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.965 ml 14.826 ml 29.652 ml 5 mM 0.593 ml 2.965 ml 5.93 ml 10 mM 0.297 ml 1.483 ml 2.965 ml 50 mM 0.059 ml 0.297 ml 0.593 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
