货号	规格	价格	上海	北京	珠海	武汉
S85834-1mg	99.60%	￥740.00 S85834-1mg ￥740.00 现货	1 1	-	-	-
S85834-5mg	≥98%	￥2400.00 S85834-5mg ￥2400.00 2-3天	0 货期：2-3天	-	-	-
S85834-25mg	99.60%	￥9500.00 S85834-25mg ￥9500.00 现货	1 1	-	-	-

货号

规格

价格

上海

北京

珠海

武汉

购买数量

S85834-1mg

99.60%

￥740.00

S85834-5mg

≥98%

￥2400.00

货期：2-3天

S85834-25mg

99.60%

￥9500.00

产品描述：

Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium. IC50 value: Target: Tacalcitol modulates immunological and inflammatory processes. Tacalcitol induces nerve growth factor production in epidermal keratinocytes.

靶点：

VD/VDR

体内研究：

Tacalcitol (0.2-20 μg/g; 涂抹于皮肤炎症区域) 软膏可缓解无毛小鼠被 TPA 诱导的皮肤炎症，改善表皮分化。

参考文献：

1. Masuo Morisaki , aoyuki Koizumi , Nobuo Ikekawa et al. Synthesis of active forms of vitamin D. Part IX. Synthesis of 1α,24-dihydroxycholecalciferol. J. Chem. Soc., Perkin Trans. 1, 1975, 1421-1424 2. Kiyoshige Ochi , Isao Matsunaga , Hiroyuki Nagano et al. Synthetic studies of vitamin D3 analogues from bile acids. Part 3. Syntheses of 1α,25-, 1α,24R-, and 1α,24S-dihydroxycholecalciferols from lithocholic acid and their biological activities. J. Chem. 3. Rostowska-Nadolska et al Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblasts. Adv.Med.Sci. (2010) 55 86. 4. Oiso N, Kawada A.Freckling Promoted by Topical Tacalcitol in a Japanese Boy with Left Eyelid Vitiligo.Pediatr Dermatol. 2011 Oct 20. 5. Kobayashi T, Okumura H, Azuma Y, Kiyoki M, Matsumoto K, Hashimoto K, Yoshikawa K.1 alpha,24R-dihydroxyvitamin D3 has an ability comparable to that of 1 alpha,25-dihydroxyvitamin D3 to induce keratinocyte differentiation.J Dermatol. 1990 Nov;17(11):707-9. 6. Matsumoto K, Hashimoto K, Kiyoki M, Yamamoto M, Yoshikawa K.Effect of 1,24R-dihydroxyvitamin D3 on the growth of human keratinocytes.J Dermatol. 1990 Feb;17(2):97-103.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.4 ml	12 ml	24.001 ml
5 mM	0.48 ml	2.4 ml	4.8 ml
10 mM	0.24 ml	1.2 ml	2.4 ml
50 mM	0.048 ml	0.24 ml	0.48 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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