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Riociguat

    
99.70%

Riociguat

源叶(MedMol)
S86010 一键复制产品信息
625115-55-1
C20H19FN8O2
422.42
利奥西呱;N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶基]-N-甲基氨基甲酸甲酯
货号 规格 价格 上海 北京 珠海 武汉 购买数量
S86010-5mg
99.70%

¥248.00

2 - - -
S86010-10mg
99.70%

¥390.00

5 - - -
S86010-25mg
99.70%

¥760.00

6 - - -
S86010-50mg
99.70%

¥1390.00

4 - - -
S86010-100mg
99.70%

¥2230.00

4 - - -
S86010-200mg
≥99%

¥3120.00

货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
靶点: sGC;Guanylatecyclase
体外研究: Riocigua stimulates the recombinant sGC concentration dependently from 0.1 to 100 μM with a two-fold to 73-fold effect by an NO-independent but haem-dependent mechanism. Riociguat inhibits platelet function in washed platelets but not in whole blood, and exerts no direct effects on contractility and relaxation of cardiac myocytes
体内研究: Riociguat (10 mg/kg/d, p.o.) partially reverses the pulmonary arterial hypertension, the right heart hypertrophy and the structural remodelling of the lung vasculature in chronic treatment of hypoxic mice and MCT-injected rats
参考文献: 1. Schermuly RT, et al. Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension. Eur Respir J. 2008 Oct;32(4):881-91. 2. Schermuly RT, et al. Riociguat for the treatment of pulmonary hypertension. Expert Opin Investig Drugs. 2011 Apr;20(4):567-76. 3. Donda K, et al. Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth. PLoS One. 2018 Jul 10;13(7):e0199927.
溶解性: soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.367 ml 11.837 ml 23.673 ml
5 mM 0.473 ml 2.367 ml 4.735 ml
10 mM 0.237 ml 1.184 ml 2.367 ml
50 mM 0.047 ml 0.237 ml 0.473 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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