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• 产品描述： RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion

• 靶点： 5-HT1B Receptor:0.38 nM (Ki);5-HT1A Receptor:2.5 nM (Ki);5-HTReceptor

• 体内研究：
  RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats. RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion Animal Model: Male Sprague-Dawley rats Dosage: 0.03, 0.3, 1.0, 3.0 mg/kg Administration: A single s.c. Result: Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.

• 参考文献：
  1. Aronsen D, et, al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep; 124: 1-4. 2. Brazell MP, et, al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol. 1985 Sep; 86(1): 209-16.

• 溶解性： Soluble  in  DMSO

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	4.38 ml	21.902 ml	43.804 ml
  5 mM	0.876 ml	4.38 ml	8.761 ml
  10 mM	0.438 ml	2.19 ml	4.38 ml
  50 mM	0.088 ml	0.438 ml	0.876 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *