S86342 |
K858 |
| 源叶(MedMol) | 98% |
- 产品描述： K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM.
- 靶点： Eg5:1.3 μM (IC50)
- 体内研究： K858 (50, 150 mg/kg, p.o.) shows antitumor activity in an A2780 ovarian cancer xenograft model, also inhibits tumor grwoth in a HCT116 colon cancer xenograft model via 100 mg/kg twice a day orally for 5 days. K858 (100 mg/kg, p.o., qd ×5) displays no neurotoxic side effects in mice
- 参考文献：
1. Nakai R, et al. K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 2009 May 1;69(9):3901-9. 2. De Iuliis F, et al. The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells. Invest New Drugs. 2016 Aug;34(4):399-406.
- 溶解性： Soluble in DMSO
- 保存条件： RT，避光
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 3.61 ml 18.051 ml 36.101 ml 5 mM 0.722 ml 3.61 ml 7.22 ml 10 mM 0.361 ml 1.805 ml 3.61 ml 50 mM 0.072 ml 0.361 ml 0.722 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
输入产品批号：
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
