S86733 |
Cevipabulin (TTI-237) |
| 源叶(MedMol) | 98% |
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- 产品描述： Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line
- 靶点： IC50: 18-40 nM (microtubule in human tumor cells)
- 体内研究： Cevipabulin (TTI-2370)( 5, 10, 15, and 20 mg/kg, every 4 days for 4 cycles, in mice) is active by i.v. and p.o. administration against human tumor xenografts, showing dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg. Animal Model: Athymic nu/nu female mice implanted s.c. in the flank with 1×107 LoVo human colon adenocarcinoma cells Dosage: 5, 10, 15, and 20 mg/kg Administration: I.V. injection every 4 days for 4 cycles. Result: The compound showed dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg.
- 参考文献：
1. Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300. 2. Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9.
- 溶解性： Soluble in DMSO
- 保存条件： 2-8℃，避光
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.151 ml 10.757 ml 21.514 ml 5 mM 0.43 ml 2.151 ml 4.303 ml 10 mM 0.215 ml 1.076 ml 2.151 ml 50 mM 0.043 ml 0.215 ml 0.43 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
