S86943 |
H1152 Dihydrochloride |
| 源叶(MedMol) | 98% |
- 提示：详情请下载说明书。
- 产品描述： H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
- 靶点： ROCKII:12 nM (IC50);CaMKII:0.18 μM (IC50);PKG:0.36 μM (IC50);AuroraA:0.745 μM (IC50);PKA:3.03 μM (IC50);Src:3.06 μM (IC50);PKC:5.68 μM (IC50);Abl:7.77 μM (IC50);MKK4:16.9 μM (IC50);MLCK:28.3 μM (IC50);EGFR:50 μM (IC50);GSK3α:60.7 μM (IC50);AMPK:100 μM (IC50);P38α:100 μM (IC50)
- 参考文献：
1. Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. Epub 2005 Sep 12. 2. Ikenoya M, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr;81(1):9-16. 3. Lie M, et al. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010 Aug 25;169(2):855-62.
- 溶解性： Soluble in DMSO、H2O
- 保存条件： 2-8℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.549 ml 12.744 ml 25.488 ml 5 mM 0.51 ml 2.549 ml 5.098 ml 10 mM 0.255 ml 1.274 ml 2.549 ml 50 mM 0.051 ml 0.255 ml 0.51 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
