S87155 |
GSK-5959 |
| 源叶(MedMol) | ≥98% (HPLC) |
- 提示：详情请下载说明书。
- 产品描述： GSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with an IC50 of ~ 80 nM
- 靶点： IC50: 80 nM (BRPF1)
- 体外研究： GSK-5959 (3a) also displays selectivity over the closely related family members, BRPF2 (100-fold) and BRPF3 (>1000-fold). GSK-5959 (3a) exhibits an EC50 = 0.98 μM) in cellular NanoBRET assay. GSK-5959 has no effect on TRIM24 SUMOylation
- 参考文献：
1. Demont EH, et al. 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. (2014) ACS Med Chem Lett. 5(11):1190-1195. 2. Wylie S.Palmer, et al. Development of small molecule inhibitors of BRPF1 and TRIM24 bromodomains Discovery Today: Technologies Volume 19, March 2016, Pages 65-71. 3. Srikanth Appikonda, et al. Cross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesionJ Biol Chem. 2018 May 11;293(19):7476-7485.
- 溶解性： Soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.535 ml 12.675 ml 25.351 ml 5 mM 0.507 ml 2.535 ml 5.07 ml 10 mM 0.254 ml 1.268 ml 2.535 ml 50 mM 0.051 ml 0.254 ml 0.507 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
输入产品批号：
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
