| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|
S87284-5mg |
99.90% | ￥265.00 |
9 | - | - | - |
|
S87284-10mg |
99.90% | ￥374.00 |
7 | - | - | - |
|
S87284-25mg |
99.90% | ￥748.00 |
7 | - | - | - |
|
S87284-50mg |
99.90% | ￥880.00 |
5 | - | - | - |
|
S87284-100mg |
99.90% | ￥1280.00 |
3 | - | - | - |
|
| 产品描述： | Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials. |
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| 靶点： | Sodium Channel;SodiumChannel | ||||||||||||||||||||
| 体内研究： | Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg) | ||||||||||||||||||||
| 参考文献： | 1. Chan SA, et al. Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia. Acta Neurochir (Wien). 1998;140(2):175-80. 2. Loscher W, et al. Anticonvulsant effect of fosphenytoin in amygdala-kindled rats: comparison with phenytoin. Epilepsy Res. 1998 Mar;30(1):69-76. | ||||||||||||||||||||
| 溶解性： | Soluble in H2O | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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