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- 产品描述： MK-3207 is an orally active, highly selective and species-specific CGRP receptor antagonist (for human CGRP receptor: IC50=0.12 nM; Ki=0.024 nM). MK-3207 can be used for migraine studies
- 靶点： CGRP Receptor
- 体内研究： MK-3207 (0.3, 0.6, 2.1, 9.1, 21.2, 60.6 µg/kg; i.v.; single) inhibits CIDV in rhesus monkeys with EC50 and Emax values of approximately 0.8 nM and 81%. MK-3207 (10 mg/kg; p.o.; single) shows the CSF/plasma ratio is 2 to 3%. Animal Model: Adult rhesus monkeys (4.8-12.7 kg; capsaicin-induced). Dosage: 0.3, 0.6, 2.1, 9.1, 21.2, 60.6 µg/kg Administration: Intravenous injection; single. Result: Resulted in an exposure-dependent decrease in capsaicin-induced dermal vasodilation in the rhesus monkey forearm.
- 参考文献：
1. Salvatore CA, Moore EL, Calamari A, Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.
- 溶解性： Soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 1.793 ml 8.967 ml 17.934 ml 5 mM 0.359 ml 1.793 ml 3.587 ml 10 mM 0.179 ml 0.897 ml 1.793 ml 50 mM 0.036 ml 0.179 ml 0.359 ml
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
