• 产品描述： FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties

• 靶点： Somatostatin release;Somatostatin

• 体内研究：
  FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease. Animal Model: Male Lister Hooded rats, weighing approximately 270-300 Dosage: 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg Administration: Administered i.p. Result: Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition.

• 参考文献：
  1. Tokita K, et al. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. Eur J Pharmacol. 2005 Dec 19;527(1-3):111-20. 2. McCarthy AD, et al. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacol Biochem Behav. 2011 Mar;98(1):76-80

• 溶解性： Soluble  in  DMSO、H2O

• 保存条件： -20°C

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.784 ml	18.918 ml	37.836 ml
  5 mM	0.757 ml	3.784 ml	7.567 ml
  10 mM	0.378 ml	1.892 ml	3.784 ml
  50 mM	0.076 ml	0.378 ml	0.757 ml

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *