欢迎光临源叶生物,登录 | 注册 |
当前位置: 首页 > 小分子化合物 > 小分子抑制剂 > E1210

商品分类

浏览历史

S87965

E1210

源叶(MedMol) 98%
  • 英文名:
  • APX001A
  • 别名:
  • CAS号:
  • 936339-60-5
  • 分子式:
  • C21H18N4O2
  • 分子量:
  • 358.39
  • 核磁/质谱:
品牌货号产品规格价格(RMB) 库存(上海) 北京 武汉 南京 数量计量单位 加入购物车...
源叶(MedMol) S87965-5mg 98% ¥1120.00元 6 0 0 0 EA 加入购物车
源叶(MedMol) S87965-10mg 98% ¥1920.00元 7 0 0 0 EA 加入购物车
源叶(MedMol) S87965-25mg 98% ¥3200.00元 6 0 0 0 EA 加入购物车
源叶(MedMol) S87965-50mg 98% ¥4700.00元 5 0 0 0 EA 加入购物车
源叶(MedMol) S87965-100mg 98% ¥6800.00元 5 0 0 0 EA 加入购物车
大包装询价

提交您的电话号码并同意《个人信息授权与保护申明》,到货后将短信提示。
提交

产品介绍

参考文献

质检证书(COA)

摩尔浓度计算器

相关产品

  • 产品描述: Manogepix (E1210) is a first-in-class, broad-spectrum and orally active antifungal. Manogepix has a mechanism of action-inhibition of fungal glycosylphosphatidylinositol (GPI) biosynthesis
  • 靶点: Fungal
  • 体外研究: Manogepix inhibits the inositol acylation activity of C. albicans Gwt1p and A. fumigatus Gwt1p with IC50s of 0.3 to 0.6 μM but has no inhibitory activity against human Pig-Wp even at concentrations as high as 100 μM. To confirm the inhibition of fungal glycosylphosphatidylinositol (GPI) biosynthesis, expression of ALS1 protein, a GPI-anchored protein, on the surfaces of C. albicans cells treated with Manogepix is studied and shown to be significantly lower than that on untreated cells. Manogepix inhibits germ tube formation, adherence to polystyrene surfaces, and biofilm formation of C. albicans at concentrations above its MIC
  • 体内研究: Manogepix (2.5 mg/kg, 5 mg/kg and 10 mg/kg; oral administration; twice daily; for 3 days; specific-pathogen-free female ICR mice) treatment reduces the number of viable C. albicans cells in the oral cavity in a dose-dependent manner. Animal Model: Specific-pathogen-free female ICR mice (5 weeks; ~25 g) with C. albicans Dosage: 2.5 mg/kg, 5 mg/kg and 10 mg/kg Administration: Oral administration; twice daily; for 3 days Result: Reduced the number of viable C. albicans cells in the oral cavity in a dose-dependent manner.
  • 参考文献:
    1. Watanabe NA, et al. E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis. Antimicrob Agents Chemother. 2012 Feb;56(2):960-71. 2. Hata K, et al. Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis. Antimicrob Agents Chemother. 2011 Oct;55(10):4543-51.
  • 溶解性: Soluble  in  DMSO
  • 保存条件: -20°C
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 2.79 ml 13.951 ml 27.903 ml
    5 mM 0.558 ml 2.79 ml 5.581 ml
    10 mM 0.279 ml 1.395 ml 2.79 ml
    50 mM 0.056 ml 0.279 ml 0.558 ml
  • 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
输入产品批号:

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:


质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)


  • =
    *
    *


源叶所有产品仅用作科学研究,销售产品行为均适用于我司网上所列通用销售条款。