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3-TYP

    
99.70%

Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI)

源叶(MedMol)
S88004 一键复制产品信息
120241-79-4
C7H6N4
146.1493
货号 规格 价格 上海 北京 珠海 南京 武汉 购买数量
S88004-5mg一口价
99.70%

¥400.00 ¥320.00

2 - - - -
S88004-10mg一口价
99.70%

¥600.00 ¥480.00

9 - - - -
S88004-50mg
99.70%

¥2000.00

3 - - - -
S88004-100mg
≥98%

¥3000.00

货期:2-3天 - - - -
S88004-500mg
99.70%

¥8000.00

1 - - - -
产品介绍 参考文献(1篇) 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: 3-TYP is a selective SIRT3 inhibitor, with an IC50 of 16 nM, more potent over SIRT1 (IC50=88 nM), SIRT2 (IC50=92 nM).
靶点: SIRT3:16 nM (IC50);SIRT1:88 nM (IC50);SIRT2:92 nM (IC50);Sirtuin
体内研究: 3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group
参考文献: 1. Pi H, et al. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015;11(7):1037-51. 2. Zhai M, et al. Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. J Pineal Res. 2017 Sep;63(2). 3. Galli U, et al. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. Eur J Med Chem. 2012 Sep;55:58-66.
溶解性: Soluble  in  DMSO、H2O、Ethanol
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 6.842 ml 34.212 ml 68.423 ml
5 mM 1.368 ml 6.842 ml 13.685 ml
10 mM 0.684 ml 3.421 ml 6.842 ml
50 mM 0.137 ml 0.684 ml 1.368 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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