货号	规格	价格	上海	北京	珠海	武汉
S88178-1mg	98%	￥300.00 S88178-1mg ￥300.00 现货	10 10	-	-	-
S88178-5mg	98%	￥618.00 S88178-5mg ￥618.00 现货	10 10	-	-	-
S88178-10mg	98%	￥824.00 S88178-10mg ￥824.00 现货	10 0 10	-	-	-
S88178-50mg	98%	￥2060.00 S88178-50mg ￥2060.00 现货	9 9	-	-	-
S88178-100mg	98%	￥3090.00 S88178-100mg ￥3090.00 现货	9 9	-	-	-
S88178-250mg	98%	￥5150.00 S88178-250mg ￥5150.00 现货	3 0 3	-	-	-

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产品描述：

E 64c is a derivative of naturally occurring epoxide inhibitor of cysteine proteases, a Calcium-activated neutral protease (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor. E 64c exhibits entry-blocking effect for MERS-CoV.

靶点：

Cysteine proteases, CANP, Cathepsin C;SARS-CoV; CysteineProtease

体内研究：

The t-1/2 of plasma E-64c is 0.48 hours. The hemodynamic effects of E-64c are absent at this dose. Using two way analysis of variance, the effects of reperfusion (p=0.0016) or E-64c (p=0.0226) per se on infarct size are significant. In comparing Group A with Group B and Group C with Group D, the depletion of CPK in the E-64c treated groups (Groups A and C) is slightly less than in the vehicle-injected groups (Groups B and D). The insufficient effect of E-64c alone may be explained by the early administration and relatively short t-1/2. Since the effectiveness of NCO-700 has been established,6),7) our findings might indicate a small but beneficial effect of E-64c on infarct size and CPK content

参考文献：

1. Khan MS, et al. Design, synthesis, evaluation and thermodynamics of 1-substituted pyridylimidazo[1,5-a]pyridine derivatives as cysteine protease inhibitors. PLoS One. 2013 Aug 5;8(8):e69982. 2. Toda G, et al. Calcium-activated neutral protease inhibitor (E-64c) and reperfusion for experimental myocardial infarction. Jpn Heart J. 1989 May;30(3):375-86. 3. Radzey H, et al. E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors. ChemMedChem. 2013 Aug;8(8):1314-21. 4. Ji Yeun Kim, et al. Safe, High-Throughput Screening of Natural Compounds of MERS-CoV Entry Inhibitors Using a Pseudovirus Expressing MERS-CoV Spike Protein. Int J Antimicrob Agents. 2018 Nov;52(5):730-732.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.181 ml	15.904 ml	31.809 ml
5 mM	0.636 ml	3.181 ml	6.362 ml
10 mM	0.318 ml	1.59 ml	3.181 ml
50 mM	0.064 ml	0.318 ml	0.636 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

阿洛司他丁酸

E-64c

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)