货号	规格	价格	上海	北京	珠海	武汉
S88187-5mg	99.70%	￥140.00 S88187-5mg ￥140.00 现货	5 5	-	-	-
S88187-10mg	99.70%	￥229.00 S88187-10mg ￥229.00 现货	7 7	-	-	-
S88187-25mg	99.70%	￥420.00 S88187-25mg ￥420.00 现货	6 6	-	-	-
S88187-50mg	99.70%	￥580.00 S88187-50mg ￥580.00 现货	5 5	-	-	-
S88187-100mg	≥98%	￥1050.00 S88187-100mg ￥1050.00 2-3天	0 货期：2-3天	-	-	-

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产品描述：

Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha. IC50 value: Target: TNF alpha Prophylactic administration of DSS-treated mice with roquinimex significantly reduced clinical signs of colitis, MDS and the CH-reduction. Moreover, in roquinimex treated animals, the MPO activity was significantly reduced by more than 50% compared to DSS control mice. Notably, therapeutic administration of roquinimex in DSS-treated mice also significantly inhibited the MDS, CH-reduction and MPO activity. Linomide, a synthetic immunomodulator, at concentrations effective in vivo reduces the number of MBP-reactive TNF-alpha and increases MBP-reactive IL-10 and TGF-beta mRNA expressing MNC from MS patients' blood when analysed in vitro. Compared to dexamethasone, Linomide up-regulated levels of blood MNC expressing mRNA of TGF-beta after culture in presence of MBP

靶点：

TNF Receptor;TNF

参考文献：

1. Roquinimex, From Wikipedia 2. Liu Q, et al. Roquinimex inhibits dextran sodium sulfate-induced murine colitis. Inflamm Res. 2003 Feb;52(2):64-8. 3. Tian WZ, et al. Linomide (roquinimex) affects the balance between pro- and anti-inflammatory cytokines in vitro in multiple sclerosis. Acta Neurol Scand. 1998 Aug;98(2):94-101.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.243 ml	16.216 ml	32.433 ml
5 mM	0.649 ml	3.243 ml	6.487 ml
10 mM	0.324 ml	1.622 ml	3.243 ml
50 mM	0.065 ml	0.324 ml	0.649 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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