S88250 |
CVT-10216 |
| 源叶(MedMol) | 98% |
- 产品描述： CVT-10216是一种高选择性、可逆的ALDH-2抑制剂，IC50为29 nM
- 靶点： ALDH-2:29 nM; ALDH-1:1.3 μM
- 体外研究： CVT-10216 significantly reduces about 50% of aldehyde dehydrogenase (ALDH) activity in OCI-AML3 cells even in the presence of recombinant TGF-β1 or BM-MSCs, sensitizing cells to chemotherapy.
- 体内研究： CVT-10216, a highly selective, reversible inhibitor of ALDH-2, exhibits both acute and prophylactic inhibitions of repeated alcohol-withdrawal-induced anxiety, which counteracts anxiogenic behavior induced by the benzodiazepine receptor inverse agonist in dose-dependently way
- 细胞实验： Cell lines: OCI-AML3 cells Concentrations: 250, 500 nM, 1, 2 µM Incubation Time: 3 days Method: OCI-AML3 cells are co-cultured with MSCs (200000 cells/well density) and treated with CVT-10216 for 3 days in the presence or absence of recombinant TGF-β1 (5 ng/mL). ALDH activity is measured by ALDEFLUOR assay using flow cytometry.
- 动物实验： Animal Models: FH, iP and Sprague Dawley (SD) rats Dosages: 3.75, 7.5, or 15 mg/kg Administration: i.p.
- 参考文献：
1. Arolfo MP, et al. Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. Alcohol Clin Exp Res. 2009 Nov;33(11):1935-44. 2. Yuan B, et al. Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway. PLoS One. 2020 Nov 30;15(11):e0242809. 3. Overstreet DH, et al. A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.
- 溶解性： Soluble in DMSO
- 保存条件： -20℃
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 2.148 ml 10.742 ml 21.483 ml 5 mM 0.43 ml 2.148 ml 4.297 ml 10 mM 0.215 ml 1.074 ml 2.148 ml 50 mM 0.043 ml 0.215 ml 0.43 ml
- 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
输入产品批号：
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)
