S88512 |
BMS-1166 |
| 源叶(MedMol) | 98% |
- 产品描述：
BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation
- 靶点： IC50: 1.4 nM (PD-1/PD-L1 interaction)
- 体外研究： BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1
- 参考文献：
1. Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867. 2. Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181.
- 溶解性： Soluble in DMSO
- 保存条件： -20°C
- 配置溶液浓度参考：
1mg 5mg 10mg 1 mM 1.56 ml 7.799 ml 15.598 ml 5 mM 0.312 ml 1.56 ml 3.12 ml 10 mM 0.156 ml 0.78 ml 1.56 ml 50 mM 0.031 ml 0.156 ml 0.312 ml
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