• 产品描述： NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

• 靶点： PEGs; Non-cleavable

• 体外研究： PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker

• 参考文献：
  1. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1. 2. Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20°C

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	4.214 ml	21.071 ml	42.143 ml
  5 mM	0.843 ml	4.214 ml	8.429 ml
  10 mM	0.421 ml	2.107 ml	4.214 ml
  50 mM	0.084 ml	0.421 ml	0.843 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *