| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|
S88829-2mg |
99.00% | ￥340.00 |
9 | - | - | - |
|
S88829-5mg |
99.00% | ￥520.00 |
5 | - | - | - |
|
S88829-10mg |
99.00% | ￥840.00 |
3 | - | - | - |
|
S88829-25mg |
≥98% | ￥1800.00 |
货期：2-3天 | - | - | - |
|
S88829-50mg |
≥98% | ￥2880.00 |
货期：2-3天 | - | - | - |
|
S88829-100mg |
≥98% | ￥4370.00 |
货期：2-3天 | - | - | - |
|
| 产品描述： | Cenerimod (ACT-334441) is a potent, selective and orally active S1P1 receptor modulator, with an EC50 of 1 nM. Cenerimod shows more than 36‐fold selctivity for hS1P1 over hS1P2, hS1P3, hS1P4, and hS1P5 receptor subtypes (EC50s=>10000, 228, 2134, and 36 nM, respectively). Cenerimod can attenuate murine experimental autoimmune encephalomyelitis (EAE) and murine sclerodermatous | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | S1PR1:1 nM (EC50);S1PR5:36 nM (EC50);S1PR5:228 nM (EC50);S1PR4:2134 nM (EC50) | ||||||||||||||||||||
| 体外研究： | Cenerimod is a highly potent S1P1 receptor agonists in (35S)-GTPγS assays using HUVEC cell membrane preparations, with an EC50 of 2 nM. Cenerimod activates G protein and increases Ca2+ signaling in CHO cells, with EC50s of 1 nM and 124 nM, respectively. Cenerimod (5 μM; 24 h) inhibits collagen production in fibroblasts | ||||||||||||||||||||
| 体内研究： | Cenerimod (0.1-10 mg/kg; a single p.o.) reversibly reduces the number of circulating lymphocytes in a dose‐dependent manner in rats. Cenerimod (6 mg/kg/day for 30 days; p.o.) attenuates disease in a mouse experimental autoimmune encephalitis (EAE) model. Cenerimod (10 mg/kg/day for 42 days; p.o.) attenuates skin and lung fibrosis in Scl-cGVHD mice. Animal Model: Male Wistar rats weighing 294-510 g Dosage: 0.1, 0.3, 1, 3 and 10 mg/kg Administration: A single p.o. Result: Effectively and reversibly reduced the blood lymphocyte counts, with a plateau reached after a single oral dose of 1 mg/kg. | ||||||||||||||||||||
| 参考文献： | 1. Piali L, et, al. Cenerimod, a novel selective S1P 1 receptor modulator with unique signaling properties. Pharmacol Res Perspect. 2017 Dec;5(6):e00370. 2. Kano M, et, al. Attenuation of murine sclerodermatous models by the selective S1P 1 receptor modulator cenerimod. Sci Rep. 2019 Jan 24;9(1):658. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京