货号	规格	价格	上海	北京	武汉	南京
S89301-5mg	≥98%	￥980.00 S89301-5mg ￥980.00 3-5天	0 货期：3-5天	-	-	-
S89301-10mg	≥98%	￥1630.00 S89301-10mg ￥1630.00 3-5天	0 货期：3-5天	-	-	-
S89301-25mg	≥98%	￥2740.00 S89301-25mg ￥2740.00 3-5天	0 货期：3-5天	-	-	-
S89301-100mg	≥98%	￥5320.00 S89301-100mg ￥5320.00 3-5天	0 货期：3-5天	-	-	-

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产品描述：

Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans

靶点：

IC50: 8.092 μM (yeast mitochondrial cytochrome bc1) ； IC50: 45.320 μM (human mitochondrial cytochrome bc1);P450

体外研究：

Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast S. cerevisiae (strain BY4741) and C. albicans (SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose.
Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both S. cerevisiae and C. albicans with IC50 value of 2.5 μM and 8.0 μM, respectively.
Inz-1 (0-100 μM; 24 hours) is selective for yeast over human cytochrome bc1, it inhibits human cytochrome bc1 activity only weakly, with an IC50 of 45.3 μM, 5.6-fold higher than the IC50 for the C. albicans homolog in mitochondria purified from HEK293 human embryonic kidney cells.
Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM，and only mildly at that concentration.
Inz-1 is against candida, human enzyme with IC50 values of 8.092 μM and 45.320 μM, respectively. It against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively.

参考文献：

1. Benjamin M Vincent, et al. A Fungal-Selective Cytochrome Bc 1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Cell Chem Biol. 2016 Aug 18;23(8):978-991.

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.755 ml	18.776 ml	37.552 ml
5 mM	0.751 ml	3.755 ml	7.51 ml
10 mM	0.376 ml	1.878 ml	3.755 ml
50 mM	0.075 ml	0.376 ml	0.751 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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