• 产品描述： Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs

• 靶点： Non-cleavable;PEGs

• 体外研究：
  ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• 参考文献：
  1. Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃，避光

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.632 ml	18.159 ml	36.317 ml
  5 mM	0.726 ml	3.632 ml	7.263 ml
  10 mM	0.363 ml	1.816 ml	3.632 ml
  50 mM	0.073 ml	0.363 ml	0.726 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *