• 产品描述： Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells

• 靶点： Topoisomerase I

• 参考文献：
  1. Burris HA 3rd, et al. Phase II trial of oral rubitecan in previously treated pancreatic cancer patients. Oncologist. 2005 Mar;10(3):183-90. 2. Rubitecan: 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitro-camptothecin, 9-nitrocamptothecin, RFS 2000, RFS2000. Drugs R D. 2004;5(5):305-11. 3. Rubitecan 4. Xia M, et al. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 2013 Jul;14(7):638-47.

• 溶解性： Soluble  in  DMSO

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.542 ml	12.711 ml	25.423 ml
  5 mM	0.508 ml	2.542 ml	5.085 ml
  10 mM	0.254 ml	1.271 ml	2.542 ml
  50 mM	0.051 ml	0.254 ml	0.508 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 2. [IF=9.965] Jianqin Yan et al."Autophagy-induced intracellular signaling fractional nano-drug system for synergistic anti-tumor therapy."JOURNAL OF COLLOID AND INTERFACE SCIENCE.2023 May;:

• 1. [IF=7.79] Yalin Sun et al."Novel polymeric micelles as enzyme-sensitive nuclear-targeted dual-functional drug delivery vehicles for enhanced 9-nitro-20(S)-camptothecin delivery and antitumor efficacy."Nanoscale. 2020 Mar;12(9):5380-5396

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *