• 产品描述： STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor cells apoptosis

• 靶点： Stat-3:1.82 μM (IC50, in HT29 cells);Stat-3:2.14 μM (IC50, in MDA-MB 231 cells);Apoptosis; STAT

• 体内研究：
  STAT3-IN-1 (compound 7d: 10, 20 mg/kg, two weeks) arrests tumor growth with low toxicity in mouse-xenograft model. Animal Model: Mouse-xenograft model bearing inoculation of mice breast cancer 4T1 cells. Dosage: 10, 20 mg/kg. Administration: Oral administration once every other day for two weeks. Result: Arrested tumor growth with no obvious body weight loss.

• 参考文献：
  1. Li S, et al. Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein. Eur J Med Chem. 2016 Nov 29;124:1006-1018.

• 溶解性： Soluble  in  DMSO

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.103 ml	10.515 ml	21.029 ml
  5 mM	0.421 ml	2.103 ml	4.206 ml
  10 mM	0.21 ml	1.051 ml	2.103 ml
  50 mM	0.042 ml	0.21 ml	0.421 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

输入产品批号：

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *