T18562 |
匹伐加宾 |
源叶(MedMol) | 98% |
- 产品描述: Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain
- 靶点: GABA Receptor
- 体内研究:
Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions. Animal Model: Adult male Sprague-Dawley CD rats (200-250 g) Dosage: 200 mg/kg Administration: i.p.; twice a day for 4 days and 1 hour before killing on the 5th day Result: Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex.
- 参考文献:
1. Esposito G, et al. Pivagabine: a novel psychoactive drug. Arzneimittelforschung. 1997 Nov;47(11A):1306-9. 2. Serra M, et al. Antagonism by pivagabine of stress-induced changes in GABAA receptor function and corticotropin-releasing factor concentrations in rat brain. Psychoneuroendocrinology. 1999 Apr;24(3):269-84.
- 溶解性: Soluble in DMSO
- 保存条件: RT
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 5.341 ml 26.704 ml 53.408 ml 5 mM 1.068 ml 5.341 ml 10.682 ml 10 mM 0.534 ml 2.67 ml 5.341 ml 50 mM 0.107 ml 0.534 ml 1.068 ml
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