• 产品描述： McN-A 343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 reduces inflammation and oxidative stress in an experimental model of ulcerative colitis.

• 靶点： AChR

• 体内研究：
  After the induction of 6% acetic acid colitis, treatment with McN-A 343 at a concentration of 1.5 mg/kg showed a significant reduction in intestinal damage as well as a decrease in wet weight, MPO activity, pro-inflammatory cytokine concentration, markers of oxidative stress and expression of inflammatory mediator

• 参考文献：
  1. Koss MC, et al. Analysis of miosis produced by McN-A-343 in anesthetized cats. J Ocul Pharmacol Ther. 1995;11(3):389-399. 2. Magalhães DA, Batista JA, Sousa SG, et al. McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis. Life Sci. 2021;272:119194.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20°C

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.152 ml	15.762 ml	31.525 ml
  5 mM	0.63 ml	3.152 ml	6.305 ml
  10 mM	0.315 ml	1.576 ml	3.152 ml
  50 mM	0.063 ml	0.315 ml	0.63 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *