别嘌醇 HPLC≥98%

Allopurinol

源叶
B27249
315-30-0
C5H4N4O
136.11
MFCD00599413
别嘌呤醇;1H-吡唑并[3,4-d]嘧啶-4-醇;4-羟基吡唑并[3,4-d]嘧啶;HPP
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶 B27249-20mg HPLC≥98% ¥300.00元 >10 1 4 2
源叶 B27249-100mg HPLC≥98% ¥1050.00元 >10 - - -
源叶 B27249-1g HPLC≥98% ¥4500.00元 >10 - - -
产品介绍 参考文献(36篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Allopurinol 是一种有效的口服活性黄嘌呤氧化酶 xanthine oxidase 抑制剂,IC50值为0.2-50 µM。Allopurinol 可用于治疗高尿酸血症和痛风。Allopurinol 降低 HIF-1α 和 HIF-2α 蛋白的表达。Allopurinol 显示出抗抑郁和抗伤害活性。Allopurinol 具有抗利什曼原虫作用。

熔点: 384°C
沸点: 290.8°C at 760 mmHg
外观: 白色至灰白色固体
溶解性: DMSO  :  14  mg/mL  (102.86  mM;  Need  ultrasonic  and  warming)
H2O  :  1  mg/mL  (7.35  mM;  ultrasonic  and  adjust  pH  to  11  with  NaOH)
敏感性: 对光敏感
储存条件: 2-8℃
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献(36篇)

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[IF=4.3] Guitao Xu et al."Eupatilin inhibits xanthine oxidase in vitro and attenuates hyperuricemia and renal injury in vivo."FOOD AND CHEMICAL TOXICOLOGY.2024 Jan;183:114307 25. [IF=5.2] Zhipeng Zheng et al."Polyphenol Composition, Antioxidant Capacity and Xanthine Oxidase Inhibition Mechanism of Furong Plum Fruits at Different Maturity Stages."Foods.2023 Jan;12(23):4253 24. [IF=5.2] Weimin Hu et al."Identification of anti-hyperuricemic components from Cichorium intybus L. taproots."Food Bioscience.10.1016/j.fbio.2023.103145 23. [IF=5] Liu Yue et al."Characterizations of microRNAs involved in the molecular mechanisms underlying the therapeutic effects of noni (Morinda citrifolia L.) fruit juice on hyperuricemia in mice."Frontiers in Nutrition.2023 Jun;10: 22. [IF=5.2] Biqian Wei et al."Guluronate oligosaccharides exerts beneficial effects on hyperuricemia and regulation of gut microbiota in mice."Food Bioscience.2023 Jun;:102855 21. [IF=4.927] Jing Chen et al."Screening of Tyrosinase, Xanthine Oxidase, and α-Glucosidase Inhibitors from Polygoni Cuspidati Rhizoma et Radix by Ultrafiltration and HPLC Analysis."MOLECULES.2023 Jan;28(10):4170 20. [IF=2.358] Ziyuan Liu et al."Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signaling pathway."NEPHROLOGY.2023 Mar;: 19. [IF=2.65] Lifei Fan et al."Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments."Evidence-based Complementary and Alternative Medicine.2023;2023:6931644 18. [IF=4.036] Pei He et al."Unveiling the inhibitory mechanism of aureusidin targeting xanthine oxidase by multi-spectroscopic methods and molecular simulations."RSC Advances.2023 Jan;13(3):1606-1616 17. [IF=6.706] Biqian Wei et al."Ameliorative Effect of Mannuronate Oligosaccharides on Hyperuricemic Mice via Promoting Uric Acid Excretion and Modulating Gut Microbiota."Nutrients.2023 Jan;15(2):417 16. [IF=6.59] Yaolei Li et al."Bioactive-Chemical Quality Markers Revealed: An Integrated Strategy for Quality Control of Chicory."Frontiers in Nutrition.2022; 9: 934176 15. [IF=6.706] Dan Wu et al."Tea (Camellia sinensis) Ameliorates Hyperuricemia via Uric Acid Metabolic Pathways and Gut Microbiota."Nutrients.2022 Jan;14(13):2666 14. [IF=4.24] Jun Li et al."In vitro xanthine oxidase inhibitory properties of Flos Sophorae Immaturus and potential mechanisms."Food Biosci. 2022 Jun;47:101711 13. [IF=3.373] Yiyuan Luo et al."Quality evaluation of Tetrastigma hemsleyanum different parts based on quantitative analysis of 42 bioactive constituents combined with multivariate statistical analysis."PHYTOCHEMICAL ANALYSIS. 2022 Apr 05 12. [IF=3.24] Yinfang Gao et al."Uricase-deficient rats with similarly stable serum uric acid to human’s are sensitive model animals for studying hyperuricemia."Plos One. 2022 Mar;17(3):e0264696 11. [IF=3.591] Yongjie Liu et al."Inhibition and molecular mechanism of diosmetin against xanthine oxidase by multiple spectroscopies and molecular docking."New J Chem. 2020 May;44(17):6799-6809 10. [IF=3.981] Wenhao Xu et al."Self-assembled nanocapsules of celery (Apium graveolens Linn) seed oil: Mechanochemical preparation, characterization and urate-lowering activity."J Drug Deliv Sci Tec. 2021 Dec;66:102810 9. [IF=4.219] Huilong Xiang et al."Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy."Toxicol Appl Pharm. 2021 Aug;424:115594 8. [IF=4.411] Xiaoke Wang et al."Novel Carbon Dots Derived from Puerariae lobatae Radix and Their Anti-Gout Effects."Molecules. 2019 Jan;24(22):4152 7. 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