82. [IF=4.8] Menglong Zhao et al."CXCL12 as a Potential Hub Gene for N-Acetylcysteine Treatment of T1DM Liver Disease."Biomolecules.2025 Feb;15(2):176 81. [IF=5.3] Shiqi Wu et al."H2S/Curcumin Coreleasing Biomineralized Zinc Sulfide Nanostructures for Diabetic Wound Healing."ACS Applied Nano Materials.2025;XXXX(XXX):XXX-XXX 80. [IF=1.3] Mei-Juan Liu et al."Xiexin Tang restores gut barrier function by regulating the differentiation of CD4+ T cells via GPRs and HDACs in T2DM rats."JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. 79. [IF=3.8] Meixian Ruan et al."Study on the active ingredients and molecular mechanisms of Polygonatum sibiricum beverage in the intervention of type 2 diabetes mellitus based on UPLC-MS, network pharmacology and experimental validation."Journal of Functional Foods. 78. [IF=4.8] Yanli Wang et al."Deciphering the effect of soluble dietary fiber from broccoli stem and leaf on metabolic syndrome and its hypoglycemic mechanism in diabetes mellitus."Food Bioscience.2025 Apr;:106546 77. [IF=4.8] Shi-Shi Qin et al."Alstonia scholaris (L.) R. Br. ameliorated diabetic nephropathy through PPAR-δ pathway."JOURNAL OF ETHNOPHARMACOLOGY.2025 May;348:119839 76. [IF=4.4] Haoxiang Sun et al."Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway."Frontiers in Pharmacology.2025 Apr;16: 75. [IF=5.6] Ji Minrui et al."Dandelion-shaped strontium-gallium microparticles for the hierarchical stimulation and comprehensive regulation of wound healing."Regenerative Biomaterials.2024 Oct;: 74. [IF=7.7] Hao Hao et al."Enzyme-mediated multifunctional self-healing lysozyme hydrogel for synergistic treatment of chronic diabetic wounds."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Dec;282:136719 73. [IF=4.4] Xing Wang et al."Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats."Frontiers in Pharmacology.2024 Dec;15: 72. [IF=4.4] Bo Yuan et al."Preventive treatment of tripdiolide ameliorates kidney injury in diabetic mice by modulating the Nrf2/NF-κB pathway."Frontiers in Pharmacology.2025 Mar;16: 71. [IF=7.7] Weiyan Yuan et al."Hyaluronic acid methacryloyl/chitosan methacryloyl/3-methacrylamidophenylboronic acid multifunctional hydrogel loading exosome for diabetic wound healing."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Sep;:135562 70. [IF=12.3] Zhang Jianhong et al."Body-worn and self-powered flexible optoelectronic device for metronomic photodynamic therapy."npj Flexible Electronics.2024 Sep;8(1):1-14 69. [IF=7.7] Shuang Liu et al."Hypoglycemic effect of orally administered resistant dextrins prepared with different acids on type 2 diabetes mice induced by high-fat diet and streptozotocin."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Oct;277:134085 68. [IF=2.6] Yukun Liu et al."Unravelling the hypoglycemic mechanism of Fuzhuan brick tea: insights into intestinal microbiota and metabolites in type 2 diabetes mellitus mice."INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY.2024 Jun;: 67. [IF=5.1] Yujia Ou et al."Porphyra haitanensis glycoprotein regulates glucose homeostasis: targeting the liver."Food & Function.2024 Jun;: 66. [IF=6.9] Yinhui Mao et al."Isorhamnetin improves diabetes-induced erectile dysfunction in rats through activation of the PI3K/AKT/eNOS signaling pathway."BIOMEDICINE & PHARMACOTHERAPY.2024 Aug;177:116987 65. [IF=5.6] Yang Yu et al."Characterization and evaluation of the in vitro and in vivo anti-diabetic activities of camel milk protein hydrolysates derived with different protease digestions."Journal of Functional Foods".2024 Jun;117:106227 64. [IF=8.6] Meiling Su et al."Sustainable deep eutectic solvents induced the polymorph selectivity and high purification efficiency."SEPARATION AND PURIFICATION TECHNOLOGY".2024 Dec;349:127856 63. [IF=9.7] Guangli Xiang et al."A Zn-MOF-GOx-based Cascade Nanoreactor Promotes Diabetic Infected Wound Healing by NO Release and Microenvironment Regulation."Acta Biomaterialia".2024 May;: 62. [IF=20.1] Zheng Ruizhu et al."Tai-Chi hydrogel with Chinese philosophy and photothermal properties for accelerated diabetic wound healing."Advanced Composites and Hybrid Materials".2024 Apr;7(2):1-19 61. [IF=5] Xingliang Xiang et al."Exploration of the hypoglycemic mechanism of Fuzhuan brick tea based on integrating global metabolomics and network pharmacology analysis."Frontiers in Molecular Biosciences.2023; 10: 1266156 60. [IF=1.6] Chen Xiaoyu et al."Faecal Untargeted Metabolomics Analysis Elucidates the Antihyperglycaemic Effect of Surfactin in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Mice."Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy.2023 Dec;: 59. [IF=5.6] Yan Lei et al."Elucidating the pharmacodynamic mechanisms of Yuquan pill in T2DM rats through comprehensive multi-omics analyses."Frontiers in Pharmacology.2023; 14: 1282077 58. [IF=6.1] Xiangnan Zhang et al."Effects of Fu brick tea polysaccharides on gut microbiota and fecal metabolites of HFD/STZ-induced type 2 diabetes rats."Food & Function.2023 Nov;: 57. [IF=2.7] Shuanji Ou et al."Tibial cortex transverse transport potentiates diabetic wound healing via activation of SDF-1/CXCR4 signaling."PeerJ.10.7717/peerj.15894 56. [IF=5.1] Ligen Chen et al."Hyperglycemia symptom amelioration by Ascophyllum nodosum polysaccharides in mice with type 2 diabetes."Algal Research-Biomass Biofuels and Bioproducts.10.1016/j.algal.2023.103278 55. [IF=5.8] Jingyu He et al."Guard against internal and external: An antibacterial, anti-inflammation and healing-promoting spray gel based on lyotropic liquid crystals for the treatment of diabetic wound."INTERNATIONAL JOURNAL OF PHARMACEUTICS.10.1016/j.ijpharm.2023. 54. [IF=3.2] Han Qingyue et al."Hippocampal transcriptome analysis reveals mechanisms of cognitive impairment in beagle dogs with type 1 diabetes."JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY.2023 Aug;: 53. [IF=3.6] Su Wu et al."Antidiabetic activity of eupafolin through peroxisome proliferator-activated receptor-gamma and PI3K/Akt signaling in Type 2 diabetic rats."JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY.2023 Aug;:e23463 52. [IF=4.3] Jin Qingsong et al."PIAS1 impedes vascular endothelial injury and atherosclerotic plaque formation in diabetes by blocking the RUNX3/TSP-1 axis."Human Cell.2023 Aug;:1-13 51. [IF=6.1] Yujia Ou et al."Gut microbiome-serum metabolism profiles insight into the hypoglycemic effect of Porphyra haitanensis glycoprotein on hyperglycemic mice."Food & Function.2023 Aug;: 50. [IF=7.9] Yinhui Mao et al."Combining transcriptomic analysis and network pharmacology to explore the mechanism by which Shaofu Zhuyu decoction improves diabetes mellitus erectile dysfunction."PHYTOMEDICINE.2023 Oct;119:155006 49. [IF=11.2] Suya Deng et al."Chitosan/silk fibroin nanofibers-based hierarchical sponges via a HClO self-producing cascade catalytic reaction accelerating infected diabetic wound healing."CARBOHYDRATE POLYMERS.2023 Aug;:121340 48. [IF=3.222] Pengmin Ji et al."Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice."RENAL FAILURE.2023;45(1):Article: 2197075 47. [IF=4.996] Li Na et al."Network pharmacology mechanism of Scutellarin to inhibit RGC pyroptosis in diabetic retinopathy."Scientific Reports.2023 Apr;13(1):1-15 46. [IF=5.6] Xing Wang et al."Gentiopicroside modulates glucose homeostasis in high-fat-diet and streptozotocin-induced type 2 diabetic mice."Frontiers in Pharmacology.2023; 14: 1172360 45. [IF=6.1] Xu Deng et al."Whole Grain Proso Millet (Panicum miliaceum L.) Attenuates Hyperglycemia in Type 2 Diabetic Mice: Involvement of miRNA Profile."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2023;XXXX(XXX):XXX-XXX 44. [IF=5.581] Ke Du et al."Feature-Based Molecular Networking Facilitates the Comprehensive Identification of Differential Metabolites in Diabetic Cognitive Dysfunction Rats."Metabolites.2023 Apr;13(4):538 43. [IF=6.317] Yunfeng Zhao et al."Onchidium struma polysaccharides exhibit hypoglycemic activity and modulate the gut microbiota in mice with type 2 diabetes mellitus."Food & Function.2023 Jan;: 42. [IF=8.025] Zerun Li et al."Interactions between structure and function of resistant glucans for alleviating type 2 diabetes mellitus (T2DM) and its complications in mice."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2023 Mar;231:123405 41. [IF=4.026] Lu, Wenjie et al."Metformin Hydrochloride Mucosal Nanoparticles-Based Enteric Capsule for Prolonged Intestinal Residence Time, Improved Bioavailability, and Hypoglycemic Effect."AAPS PHARMSCITECH.2023 Jan;24(1):1-14 40. [IF=8.025] Gang Xiang et al."Antioxidant and hypoglycemic activity of tea polysaccharides with different degrees of fermentation."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2022 Dec;: 39. [IF=5.195] Yuli Han et al."Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice."JOURNAL OF ETHNOPHARMACOLOGY.2022 Nov;:115923 38. [IF=3.654] Xuejing Zhang et al."Black Rice Anthocyanidins Regulates Gut Microbiota and Alleviates Related Symptoms through PI3K/AKT Pathway in Type 2 Diabetic Rats."JOURNAL OF FOOD BIOCHEMISTRY.2023;2023:5876706 37. [IF=5.223] Mubai Sun et al."Analysis of the alleviating effect of black bean peel anthocyanins on type 2 diabetes based on gut microbiota and serum metabolome."Journal of Functional Foods.2023 Mar;102:105456 36. [IF=6.317] Zirui Huang et al."Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice."Food & Function.2022 Oct;: 35. [IF=5.223] Zimu Zhang et al."Intestinal microbiology and metabolomics of streptozotocin-induced type 2 diabetes mice by polysaccharide from Cardamine violifolia."Journal of Functional Foods.2022 Oct;97:105251 34. [IF=9.381] Yuanping Hao et al."Carboxymethyl chitosan-based hydrogels containing fibroblast growth factors for triggering diabetic wound healing."Carbohyd Polym. 2022 Jul;287:119336 33. [IF=2.952] Yunfeng Zhu et al."Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy."Mol Med Rep. 2021 Jun;23(6):1-12 32. [IF=4.076] Lihua Li et al."Artesunate alleviates diabetic retinopathy by activating autophagy via the regulation of AMPK/SIRT1 pathway."ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY. 2021 Mar 04 31. [IF=4.219] Zhenlong Qin et al."Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models."Saudi J Biol Sci. 2020 Sep;27:2485 30. [IF=4.545] Zhongyuan Wang et al."Protective effects of AS-IV on diabetic cardiomyopathy by improving myocardial lipid metabolism in rat models of T2DM."Biomed Pharmacother. 2020 Jul;127:110081 29. [IF=5.396] Yue Ding et al."Combination of honey with metformin enhances glucose metabolism and ameliorates hepatic and nephritic dysfunction in STZ-induced diabetic mice."Food Funct. 2019 Nov;10(11):7576-7587 28. [IF=5.396] Jun-ping Liu et al."Antidiabetic activities of glycoprotein from pea (Pisum sativum L.) in STZ-induced diabetic mice."Food Funct. 2021 Jun;12(11):5087-5095 27. [IF=5.396] Xiaopeng Li et al."Diabetes diminishes a typical metabolite of litchi pericarp oligomeric procyanidins (LPOPC) in urine mediated by imbalanced gut microbiota."Food Funct. 2021 Jun;12(12):5375-5386 26. Li, Xiaopeng, et al. "Attenuated mTOR signaling and enhanced glucose homeostasis by dietary supplementation with lotus seedpod oligomeric procyanidins in streptozotocin (STZ)-induced diabetic mice." Journal of agricultural and food chemistry 65.19 (2017): 25. Li, Xiaopeng, et al. "A-type procyanidins from litchi pericarp ameliorate hyperglycaemia by regulating hepatic and muscle glucose metabolism in streptozotocin (STZ)-induced diabetic mice fed with high fat diet." Journal of Functional Foods 27 (2016): 711-7 24. Ding, Yue, et al. "Combination of honey with metformin enhances glucose metabolism and ameliorates hepatic and nephritic dysfunction in STZ-induced diabetic mice." Food & function 10.11 (2019): 7576-7587.https://doi.org/10.1039/C9FO01575B 23. Jayachandran, Muthukumaran, Ramachandran Vinayagam, and Baojun Xu. "Guava leaves extract ameliorates STZ induced diabetes mellitus via activation of PI3K/AKT signaling in skeletal muscle of rats." Molecular biology reports 47.4 (2020): 2793-2799. 22. Wei Xu, Qing Zhou, Jiao-jiao Yin, Yong Yao, Jiu-liang Zhang, Anti-diabetic effects of polysaccharides from Talinum triangulare in streptozotocin (STZ)-induced type 2 diabetic male mice, International Journal of Biological Macromolecules, Volume 72, 2015, P 21. Jayachandran, Muthukumaran, et al. "Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats." Chemico-biological interactions 303 (2019): 62-69.https://doi.org/10.1016 20. Li, Xiaopeng, et al. "Dietary supplementation of A-type procyanidins from litchi pericarp improves glucose homeostasis by modulating mTOR signaling and oxidative stress in diabetic ICR mice." Journal of Functional Foods 44 (2018): 155-165.https://doi.org/1 19. 闫爽,李光耀,戴丛书,崔昊震,柳振宇,林长青.人参皂苷CK对2型糖尿病大鼠肝损伤的保护机制[J].食品工业科技,2021,42(02):310-315. 18. 随风,时昭红.胰高血糖样肽1对非酒精性脂肪肝大鼠CFHR1～5表达的影响[J].中国免疫学杂志,2021,37(01):36-40. 17. 季天娇. 黄芪甲苷调节PI3K/Akt通路来改善2型糖尿病大鼠肝糖代谢异常的分子机制[D].安徽医科大学,2020. 16. 马可可,鞠营辉,陈清青,李维祖,李卫平.黄芪甲苷对2型糖尿病肾病大鼠肾组织PI3K/Akt/FoxO1信号调控的影响[J].中国实验方剂学杂志,2019,25(02):74-81. 15. 李丽, 黄雪梦, 杨璐嘉,等. 采用2种降糖模型考察核桃蛋白及多肽的降糖作用[J]. 食品科技, 2017, 042(004):218-221. 14. 袁利佳,张蕾,张晓东.蝙蝠蛾拟青霉菌粉对糖尿病模型大鼠的保护作用[J].食用菌学报,2018,25(02):99-104+167. 13. 张哲滔,车念聪,郑亚琳,田甜,魏晓艺,刘晔.菖蒲郁金汤化裁方对2型糖尿病合并非酒精性脂肪肝大鼠SREBP-1c表达和胰岛素抵抗的影响[J].北京中医药,2019,38(01):17-20+97. 12. 王海生, 谢永财, 李长征,等. 石斛合剂对高脂高糖糖尿病大鼠心肌细胞Ca2+代谢的影响[J]. 福建中医药, 2020, 051(001):47-50. 11. 王航利, 张梦迪, 黄绳武. 益气补阴方对气阴两虚证糖尿病大鼠的降血糖作用研究[J]. 中药新药与临床药理, 2020(8). 10. 伏瑶,周继栋,桑晓宇,孙笛洋,赵启韬,傅风华.瓜蒌薤白半夏汤对2型糖尿病合并急性心肌缺血大鼠造血干细胞的保护作用机制[J].中华中医药杂志,2020,35(05):2613-2617. 9. 汤陈鹏, 吕峰, 刘伊娜. 孔石莼多糖锌对Ⅰ型糖尿病小鼠糖脂代谢及体内抗氧化的干预作用[J]. 食品工业科技, 2020, v.41;No.441(01):301-306+315. 8. 胡江, 缪菁, 段淑芳,等. 大黄酸对2型糖尿病模型大鼠的保护作用[J]. 中国药房, 2014, 025(023):2113-2116. 7. 杨文超, 顾正位, 路其康,等. 复方葛根片对糖尿病肾病模型大鼠肾组织的保护作用[J]. 中国药房, 2015(34). 6. 孙昕, 刘卫. 复方川芎滴丸对糖尿病肾病模型大鼠血液流变学及血气的影响[J]. 中国药房, 2017(7). 5. 崔祥,尚尔鑫,江曙,钱大玮,段金廒.基于响应曲面法对黄芩-黄连配伍改善2型糖尿病糖脂代谢紊乱的相互作用研究[J].药学学报,2018,53(04):630-635. 4. 张文锦 方朝晖 赵媛媛 等. 启元胶囊对糖尿病模型大鼠周围神经病变干预机制[J]. 中医药临床杂志 2019 v.31(11):120-123. 3. 吉艳梅 文彩铃.六味地黄丸联合胰岛素对妊娠糖尿病大鼠血清皮质酮及胎盘11β-羟基类固醇脱氢酶表达的影响[J].解放军药学学报 2018 34(03):221-224+253. 2. 周国佩 吴帆 朱金华 et al. 乌梅丸对2型糖尿病模型大鼠肠道菌群 炎性因子及短链脂肪酸的影响[J]. 中国实验方剂学杂志 2020(10). 1. 朱戈丽 伍军 张艳霞 等. miR-21介导PTEN/SMAD7信号传导通路调控糖尿病肾病大鼠肾纤维化作用研究[J]. 临床误诊误治 2020年33卷7期 104-108页 ISTIC 2020.