| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80028-1mg |
99.5% | ￥221.00 | 9 | - | - | - |
|
S80028-2mg |
99.5% | ￥391.00 | 10 | - | - | - |
|
S80028-5mg |
99.5% | ￥595.00 | 7 | - | - | - |
|
S80028-10mg |
99.5% | ￥1180.00 | 7 | - | - | - |
|
S80028-25mg |
99.5% | ￥2800.00 | 5 | - | - | - |
|
S80028-50mg |
≥99% | ￥3400.00 | 货期：2-3天 | - | - | - |
|
S80028-100mg |
≥99% | ￥5000.00 | 货期：2-3天 | - | - | - |
|
SGI-1776 is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively.
| 产品描述： | SGI-1776 is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Ki: 7 nM (Pim-1), 363 nM (Pim-2), 69 nM (Pim-3);Apoptosis;FLT;Pim;Autophagy | ||||||||||||||||||||
| 体内研究： | SGI-1776 (75, 200 mg/kg, p.o.) shows potent and sustained antitumor activity in a dose dependent manner in MV-4-11 xenografts | ||||||||||||||||||||
| 参考文献： | 1. Hou X, et al. Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776. Exp Cell Res. 2017 Mar 15;352(2):403-411. 2. Park YK, et al. The novel anti-adipogenic effect and mechanisms of action of SGI-1776, a Pim-specific inhibitor, in 3T3-L1 adipocytes. Int J Mol Med. 2016 Jan;37(1):157-64 3. Xie J, et al. SGI-1776, an imidazo pyridazine compound, inhibits the proliferation of ovarian cancer cells by inactivating Pim-1. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Jul;39(7):649-57 4. Chen LS, et al. Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood, 2011, 118(3), 693-702. | ||||||||||||||||||||
| 溶解性： | DMSO : 125 mg/mL (308.32 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京