货号	规格	价格	上海	北京	武汉	南京
S80029-1mg	98.5%	￥100.00 S80029-1mg ￥100.00 现货	3 3	-	-	-
S80029-2mg	98.5%	￥140.00 S80029-2mg ￥140.00 现货	6 6	-	-	-
S80029-5mg	98.5%	￥170.00 S80029-5mg ￥170.00 现货	5 5	-	-	-
S80029-10mg	98.5%	￥180.00 S80029-10mg ￥180.00 现货	5 5	-	-	-
S80029-25mg	98.5%	￥400.00 S80029-25mg ￥400.00 现货	2 2	-	-	-
S80029-50mg	≥98%	￥610.00 S80029-50mg ￥610.00 2-3天	0 货期：2-3天	-	-	-
S80029-100mg	≥98%	￥990.00 S80029-100mg ￥990.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

Fostamatinib Disodium (R788 Disodium) is the oral prodrug of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)

产品描述：

靶点：

Syk, FLT3;FLT;Syk

体内研究：

Fostamatinib (R788) is highly bioavailable, and rapidly absorbed in Louvain rats. R406 following a single oral dose of R788 10 mg/kg or 20 mg/kg: AUC0-16 hrs= 10618 ng*h/mL and 30650 ng*h/mL respectively; Cmax=2600 ng/mL and 6500 ng/mL respectively (observed at 1 hour); t1/2=4.2 hours. The prodrug was not detected in plasma suggesting R788 is completely converted to R406

参考文献：

1. Stephen P McAdoo, et al. Fostamatinib Disodium. Drugs Future. 2011;36(4):273. 2. Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008. 3. Hoon-Suk Cha , et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May;317(2):571-8.

溶解性：

DMSO : 20.83 mg/mL (33.36 mM; ultrasonic and warming and heat to 60°C) H2O : ≥ 1 mg/mL (1.60 mM)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.601 ml	8.007 ml	16.015 ml
5 mM	0.32 ml	1.601 ml	3.203 ml
10 mM	0.16 ml	0.801 ml	1.601 ml
50 mM	0.032 ml	0.16 ml	0.32 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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R788 (Fostamatinib) Disodium