| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80030-1mg买3赠1 |
98.00% | ￥150.00 |
9 | - | - | - | - |
|
S80030-2mg买3赠1 |
98.00% | ￥285.00 |
9 | - | - | - | - |
|
S80030-5mg买3赠1 |
98.00% | ￥315.00 |
7 | - | - | - | - |
|
S80030-10mg买3赠1 |
98.00% | ￥540.00 |
5 | - | - | - | - |
|
S80030-25mg买3赠1 |
98.00% | ￥1080.00 |
2 | - | - | - | - |
|
S80030-50mg买3赠1 |
≥98% | ￥1550.00 |
货期：2-3天 | - | - | - | - |
|
S80030-100mg |
≥98% | ￥2490.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases | ||||||||||||||||||||
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| 靶点： | IC50: 3.9 nM (c-Met), 1.1 nM (Axl), 1.8 nM (Ron), 4.3 nM (Tyro3);c-Met/HGFR;TAMReceptor | ||||||||||||||||||||
| 体内研究： | Oral administration of BMS 777607 (6.25-50 mg/kg) significantly reduces tumor volumes of the GTL-16 human tumor xenografts in athymic mice with no observed toxicity. Administration of BMS 777607 (25 mg/kg/day) decreases the number of KHT lung tumor nodules (28.3%), improves the morphological hemorrhage, and significantly impairs the metastatic phenotype in the 6-8 week-old female C3H/HeJ mice injected with rodent fibrosarcoma KHT cells without apparent systemic toxicity compared to the control treatment. A low dose of BMS 777607 (10 mg/kg) also offers a mild but not significant inhibition of lung nodule formation compared to the vehicle control. | ||||||||||||||||||||
| 参考文献： | 1. Schroeder GM, et al. Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily. J Med Ch 2. Dai Y, et al. BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro. Mol Cancer Ther, 2010, 9(6), 1554-1561. 3. Dai Y, et al. Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation. Clin Exp Metastasis, 2012, 29, 253-261. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 39 mg/mL (76.04 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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