| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80088-5mg促销 |
≥98% | ￥594.00 ￥534.00 |
10 | - | - | - | - |
|
S80088-10mg促销 |
≥98% | ￥905.00 ￥814.00 |
10 | - | - | - | - |
|
S80088-25mg促销 |
≥98% | ￥1850.00 ￥1660.00 |
10 | - | - | - | - |
|
S80088-50mg促销 |
≥98% | ￥2960.00 ￥2660.00 |
10 | - | - | - | - |
|
S80088-100mg促销 |
≥98% | ￥4630.00 ￥4170.00 |
6 | - | - | - | - |
|
S80088-250mg促销 |
≥98% | ￥9260.00 ￥8340.00 |
1 | - | - | - | - |
|
| 产品描述： | CCT 137690 is a potent and orally available aurora kinase inhibitor with IC50s of 15, 25, and 19 nM for aurora A, B and C, respectively. | ||||||||||||||||||||
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| 靶点： | Aurora A:15 nM (IC50);Aurora B:25 nM (IC50);Aurora C:19 nM (IC50);Apoptosis;AuroraKinase;Autophagy | ||||||||||||||||||||
| 体内研究： | CCT 137690 slows the growth of the SW620 xenografts with no observed toxicity. CCT 137690 significantly inhibits tumour growth in a transgenic mouse model of neuroblastoma (TH-MYCN) that overexpresses MYCN protein and is predisposed to spontaneous neuroblastoma formation | ||||||||||||||||||||
| 参考文献： | 1. Bavetsias V, et al. Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J Med Chem. 2010 Jul 22;53(14):5213-28. 2. Faisal A, et al. The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol Cancer Ther. 2011 Nov;10(11):2115-23. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京