| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80996-1mg买3赠1 |
≥98% | ￥306.00 |
>10 | - | - | - | - |
|
S80996-2mg买3赠1 |
≥98% | ￥552.00 |
>10 | - | - | - | - |
|
S80996-5mg买3赠1 |
≥98% | ￥722.00 |
>10 | - | - | - | - |
|
S80996-10mg买3赠1 |
≥98% | ￥1190.00 |
>10 | - | - | - | - |
|
S80996-25mg买3赠1 |
≥98% | ￥2380.00 |
>10 | - | - | - | - |
|
S80996-50mg买3赠1 |
≥98% | ￥4080.00 |
10 | - | - | - | - |
|
S80996-100mg |
≥98% | ￥6700.00 |
5 | - | - | - | - |
|
| 产品描述： | ADL-5859 (compound 20) is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM, respectively. ADL-5859 also shows inhibitory activity to hERG channel with an IC50 value of 78 μM. ADL-5859 can be used for the research of pain | ||||||||||||||||||||
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| 靶点： | IC50: 78 μM (hERG channel), 43 μM (CYP2D6);OpioidReceptor | ||||||||||||||||||||
| 体内研究： | ADL-5859 (0.3-10 mg/kg; p.o. once) reverses hyperalgesia in inflamed paw of rats and shows robust antidepressant-like activity | ||||||||||||||||||||
| 参考文献： | 1. Le Bourdonnec B, et al. Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859). J Med Chem. 2008 Oct 9;51(19):5893-6. 2. Le Bourdonnec B, et al. Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).J Med Chem. 2009 Sep 24;52(18):5685-702. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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