货号	规格	价格	上海	北京	珠海	重庆	武汉
S81007-10mg促销	98.10%	￥280.00 ￥224.00 S81007-10mg ￥224.00 现货	11 >10	-	-	-	-
S81007-25mg促销	98.10%	￥464.00 ￥370.00 S81007-25mg ￥370.00 现货	6 6	-	-	-	-
S81007-50mg促销	≥98%	￥840.00 ￥672.00 S81007-50mg ￥672.00 2-3天	0 货期：2-3天	-	-	-	-
S81007-100mg促销	≥98%	￥1480.00 ￥1180.00 S81007-100mg ￥1180.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research.

靶点：

HDAC

体内研究：

MC1568 shows an apparent tissue-selective HDAC inhibition. In skeletal muscle and heart, MC1568 inhibits the activity of HDAC4 and HDAC5 without affecting HDAC3 activity, thereby leaving MEF2–HDAC complexes in a repressed state. MC1568 increases mortality and lesion volume and did not improve functional outcome. In addition, MC1568 decreases microtubule associated protein 2, phosphorylated neurofilament heavy chain and myelin basic protein immunoreactivity in the periinfarct cortex

参考文献：

1. Nebbioso A, et al. Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity ofHDAC-MEF2 complexes. EMBO Rep. 2009 Jul;10(7):776-82. 2. Venza I, et al. Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204. 3. Nebbioso A, et al. HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation. J Mol Endocrinol. 2010 Oct;45(4):219-28. 4. Kassis H, et al. Class IIa histone deacetylases affect neuronal remodeling and functional outcome after stroke. Neurochem Int. 2016 Jun;96:24-31.

溶解性：

DMSO : 18.5 mg/mL (58.86 mM; Need ultrasonic and warming)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.182 ml	15.908 ml	31.816 ml
5 mM	0.636 ml	3.182 ml	6.363 ml
10 mM	0.318 ml	1.591 ml	3.182 ml
50 mM	0.064 ml	0.318 ml	0.636 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

MC1568

(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)