货号	规格	价格	上海	北京	珠海	重庆	武汉
S81039-5mg买3赠1	98.10%	￥100.00 S81039-5mg ￥100.00 现货（买3赠1）	7 7	-	-	-	-
S81039-10mg买3赠1	98.10%	￥120.00 S81039-10mg ￥120.00 现货（买3赠1）	7 7	-	-	-	-
S81039-25mg买3赠1	98.10%	￥245.00 S81039-25mg ￥245.00 现货（买3赠1）	5 5	-	-	-	-
S81039-50mg买3赠1	98.10%	￥400.00 S81039-50mg ￥400.00 现货（买3赠1）	6 6	-	-	-	-
S81039-100mg买3赠1	98.10%	￥680.00 S81039-100mg ￥680.00 现货（买3赠1）	4 4	-	-	-	-
S81039-200mg买3赠1	98.10%	￥1220.00 S81039-200mg ￥1220.00 现货（买3赠1）	4 4	-	-	-	-

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产品描述：

GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling

靶点：

IC50: 60 nM (c-FMS);c-Fms

体内研究：

GW2580 (Oral administration; 20 and 80 mg/kg) produces a dose-related decrease in the number of tumor cells, with the 80 mg/kg dose completely blocking tumor growth. GW2580 (Oral administration; 20 and 80 mg/kg) has gave maximal plasma concentrations of 1.4 and 5.6 μM, respectively. GW2580 (50 mg/kg; twice a day from days 0 to 21, 7 to 21, or 14 to 21) inhibits joint connective tissue and bone destruction in a 21-day adjuvant arthritis model.

参考文献：

1. Conway JG, et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83. 2. Priceman SJ, et al. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood. 2010 Feb 18;115(7):1461-71 3. Conway JG, et al. Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J Pharmacol Exp Ther. 2008 Jul;326(1):41-50.

溶解性：

DMSO : 33.33 mg/mL (90.96 mM; Need ultrasonic) Ethanol : < 1 mg/mL (insoluble)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.729 ml	13.646 ml	27.292 ml
5 mM	0.546 ml	2.729 ml	5.458 ml
10 mM	0.273 ml	1.365 ml	2.729 ml
50 mM	0.055 ml	0.273 ml	0.546 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(3篇)

3. [IF=4.9] Xin Li et al."Paeonol Relieves Chronic Neuropathic Pain by Reducing Communication Between Schwann Cells and Macrophages in the Dorsal Root Ganglia After Injury."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2025 Jan;26(9):3964 2. [IF=5.5] Waimei Si et al."Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R."CNS Neuroscience & Therapeutics".2024 Apr;30(4):e14657 1. [IF=5.1] Jing Bei et al."(+)-Catechin Alleviates CCI-Induced Neuropathic Pain in Rats by Modulating the IL34/CSFIR Axis and Attenuating the Schwann Cell-Macrophage Cascade Response in the DRG."MOLECULAR NEUROBIOLOGY.2023 Dec;:1-15

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