| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81151-5mg买3赠1 |
97.50% | ￥166.00 |
8 | - | - | - | - |
|
S81151-10mg买3赠1 |
97.50% | ￥268.00 |
6 | - | - | - | - |
|
S81151-25mg买3赠1 |
97.50% | ￥490.00 |
6 | - | - | - | - |
|
S81151-50mg买3赠1 |
97.50% | ￥910.00 |
6 | - | - | - | - |
|
S81151-100mg买3赠1 |
97.50% | ￥1470.00 |
4 | - | - | - | - |
|
S81151-200mg买3赠1 |
≥97% | ￥2130.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | A-803467 is a potent and selective tetrodotoxin-resistant Nav1.8 sodium channel blocker (IC50=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter | ||||||||||||||||||||
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| 靶点： | Nav1.8:8 nM (IC50);SodiumChannel | ||||||||||||||||||||
| 体内研究： | A-803467 (35 mg/kg; p.o.) shows no noticeable toxicity in the male NCR nude mice. A-803467 in combination with topotecan, significantly decreases the tumor growth in mice implanted with ABCG2 overexpressing H460/MX20 cells. A-803467 effectively restores the sensitivity of tumors overexpressing ABCG2 transporter to topotecan without having any significant effect on tumors lacking ABCG2 expression. | ||||||||||||||||||||
| 参考文献： | 1. Anreddy N, et al. A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo. Oncotarget. 2015;6(36):39276-39291. 2. Jarvis MF, et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A. 2007;104(20):8520-8525. | ||||||||||||||||||||
| 溶解性： | DMSO : 50 mg/mL (139.75 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京