货号	规格	价格	上海	北京	武汉	南京
S81232-2mg	99.1%	￥100.00 S81232-2mg ￥100.00 现货	5 5	-	-	-
S81232-5mg	99.1%	￥170.00 S81232-5mg ￥170.00 现货	6 6	-	-	-
S81232-10mg	99.1%	￥320.00 S81232-10mg ￥320.00 现货	6 6	-	-	-
S81232-25mg	99.1%	￥430.00 S81232-25mg ￥430.00 现货	6 6	-	-	-
S81232-50mg	≥99%	￥620.00 S81232-50mg ￥620.00 2-3天	0 货期：2-3天	-	-	-
S81232-100mg	≥99%	￥860.00 S81232-100mg ￥860.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.

产品描述：

AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.

靶点：

Apoptosis;Autophagy;Pim;Apoptosis; Pim; Autophagy

体内研究：

AZD1208在培养的MOLM-16细胞中引起细胞周期停滞和细胞凋亡。这伴随着BAD,4EBP1和p70S6K磷酸化的剂量依赖性降低。另外,AZD1208导致有效抑制来自骨髓抽吸物的原代AML细胞的集落生长并下调Pim靶标的磷酸化

细胞实验：

AZD1208 is dissolved in DMSO. MOLM-16 cells, purchased from DSMZ and cultured in RPMI containing 10% fetal bovine serum (FBS) and 1% L-glutamine, are plated at 20,000 cells per well in 96 well plates overnight. Cells are treated for 72 hours with compound or control vehicle (dimethyl sulfoxide) and cell viability is measured after the addition of Cell Titer-Blue for 4 hours at 37?C and reading of fluorescence on a Tecan Infinite? 200. The GI50 is determined by calculating growth at each dose relative to vehicle treated cells and cell viability at the time of treatment.

参考文献：

1.Erika Keeton, et al. 53rd ASH Annual Meeting (2011) Abstract nr 1540

溶解性：

DMSO:7.6 mg/mL (20 mM)),with gentle warming

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.635 ml	13.176 ml	26.352 ml
5 mM	0.527 ml	2.635 ml	5.27 ml
10 mM	0.264 ml	1.318 ml	2.635 ml
50 mM	0.053 ml	0.264 ml	0.527 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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