| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81268-2mg买3赠1 |
99.70% | ￥204.00 |
5 | - | - | - | - |
|
S81268-5mg买3赠1 |
99.70% | ￥382.00 |
10 | - | - | - | - |
|
S81268-10mg买3赠1 |
99.70% | ￥510.00 |
8 | - | - | - | - |
|
S81268-50mg买3赠1 |
99.70% | ￥890.00 |
10 | - | - | - | - |
|
S81268-100mg买3赠1 |
99.70% | ￥1160.00 |
6 | - | - | - | - |
|
S81268-1g买3赠1 |
99.70% | ￥4500.00 |
6 | - | - | - | - |
|
| 产品描述： | Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy |
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| 靶点： | Bcl-2：0.01 nM (Ki)；Bcl-xL：48 nM (Ki)；Bcl-W：245 nM (Ki);BCL; Autophagy | ||||||||||||||||||||
| 体内研究： | After a single oral dose of 12.5 mg per kg body weight in xenografts derived from RS4;11 cells (ALL), Venetoclax (ABT-199) causes a maximal tumor growth inhibition (TGImax) of 47% (P<0.001) and tumor growth delay (TGD) of 26% (P<0.05). Treatment of established xenografted (a mouse xenograft model of the T-ALL cell line LOUCY) tumors with Venetoclax (ABT-199) 100 mg/kg for 4 days results in a significant reduction of leukemic burden. | ||||||||||||||||||||
| 参考文献： | 1. Souers AJ, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8. 2. Peirs S, et al. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. Blood. 2014 Dec 11;124(25):3738-47. 3. Bi C, et al. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Haematologica. 2017 Apr;102(4):755-764. | ||||||||||||||||||||
| 溶解性： | DMSO : 77.5 mg/mL (89.24 mM; Need ultrasonic) Ethanol : < 1 mg/mL (insoluble) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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