| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81322-2mg |
99.1% | ￥200.00 | 5 | - | - | - |
|
S81322-5mg |
99.1% | ￥280.00 | 6 | - | - | - |
|
S81322-10mg |
99.1% | ￥450.00 | 6 | - | - | - |
|
S81322-25mg |
99.1% | ￥815.00 | 6 | - | - | - |
|
S81322-50mg |
≥99% | ￥1440.00 | 货期：2-3天 | - | - | - |
|
S81322-100mg |
≥99% | ￥2300.00 | 货期：2-3天 | - | - | - |
|
S81322-200mg |
≥99% | ￥3700.00 | 货期：2-3天 | - | - | - |
|
AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an EGFR inhibitor with IC50s of 1, 6, 1, 25 and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively.
| 产品描述： | AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an EGFR inhibitor with IC50s of 1, 6, 1, 25 and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | EGFRL858R/T790M:1 nM (IC50);EGFRL858R:1 nM (IC50);EGFRL861Q:6 nM (IC50);EGFR:25 nM (IC50);ErbB4:7 nM (IC50);EGFRExon 19 deletion/T790M;EGFR | ||||||||||||||||||||
| 体外研究： | AZ-5104 inhibits EGFR phosphorylation with IC50s of 2, 1, 2, 53, and 33 nM in H1975 (EGFRL858R/T790M), PC-9VanR (EGFRExon 19 deletion/T790M), PC-9 (EGFRExon 19 deletion), H2073 (WT), and LOVO (WT), respectively. AZ5104 exhibits a reduced selectivity margin against wild-type EGFR when compared to AZD9291. AZ5104 display minimal off-target activity against other non-HER family kinases, but has the potential to target both HER2 and HER4 kinase activity | ||||||||||||||||||||
| 体内研究： | The metabolite, AZ5104 (5 mg/kg/day), is effective in shrinking tumors in both C/L858R and C/L+T mice | ||||||||||||||||||||
| 参考文献： | 1. Cross DA, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4(9):1046-61. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京