| 产品描述： | Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. |
| 靶点： |
SIRT2:28 nM (IC50);SIRT1:98 μM (IC50);Sirtuin |
| 体内研究： |
TM inhibits tumor growth in mouse models of breast cancer. TM does not cause significant toxicity in mice and no significant weight loss is observed in TM-treated mice. S5H, the acetyl-a-tubulin level is moderately but statistically significantly increased in tumors from TM-treated mice compared with those from vehicle-treated mice, suggesting that TM indeed inhibits SIRT2 in vivo |
| 参考文献： |
1. Jing H, et al. A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell. 2016 Mar 14;29(3):297-310. |
| 溶解性： |
DMSO : ≥ 32 mg/mL (55.00 mM) Ethanol : 15.29 mg/mL (26.28 mM; Need ultrasonic) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.719 ml |
8.593 ml |
17.187 ml |
| 5 mM |
0.344 ml |
1.719 ml |
3.437 ml |
| 10 mM |
0.172 ml |
0.859 ml |
1.719 ml |
| 50 mM |
0.034 ml |
0.172 ml |
0.344 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京