| 产品描述： | Bazedoxifene acetate (TSE-424 acetate) is an oral, nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene acetate can be used for the research of osteoporosis. Bazedoxifene acetate also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer |
| 靶点： |
IC50: 26 nM (ERα), 99 nM (ERβ);EstrogenReceptor/ERR; Estrogen/progestogenReceptor |
| 体内研究： |
Bazedoxifene acetate (5 mg/kg; i.g.; daily, for 18 days) inhibits Capan-1 tumor growth in mouse model in vivo |
| 参考文献： |
1. Barry S Komm, et al. Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology. 2005 Sep;146(9):3999-4008. 2. Xiaojuan Wu, et al. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Mol Cancer Ther. 2016 Nov; 15(11): 2609–2619. |
| 溶解性： |
DMSO : ≥ 100 mg/mL (188.45 mM) H2O : < 0.1 mg/mL (insoluble) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.884 ml |
9.422 ml |
18.845 ml |
| 5 mM |
0.377 ml |
1.884 ml |
3.769 ml |
| 10 mM |
0.188 ml |
0.942 ml |
1.884 ml |
| 50 mM |
0.038 ml |
0.188 ml |
0.377 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京