| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81483-10mg促销 |
98.00% | ￥150.00 ￥120.00 |
2 | 1 | - | - | - |
|
S81483-50mg促销 |
98.00% | ￥350.00 ￥280.00 |
3 | - | - | - | - |
|
S81483-250mg促销 |
98.00% | ￥590.00 ￥472.00 |
8 | - | - | - | - |
|
S81483-1g促销 |
≥98% | ￥1800.00 ￥1440.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Pirinixic acid (Wy-14643) is a potent agonist of PPARα, with EC50s of 0.63 μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 μM for human PPARα, PPARγ and PPARδ, respectively. | ||||||||||||||||||||
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| 靶点： | PPARα:0.63 μM (EC50);PPARγ:32 μM (EC50);PPAR | ||||||||||||||||||||
| 体内研究： | Pirinixic acid (Wy-14643; 10 mg/kg, i.v.) decreases hepatic injury and lipid peroxidation (MDA) levels in obese rats. Pirinixic acid also causes increased SIRT1 activity in Sham and ischemia-reperfusion (IR) group, but shows no effects on SIRT3 protein expression. Pirinixic acid enhances NAD+, and ATP levels, and prevents endoplasmic reticulum stress (ERS) in rats | ||||||||||||||||||||
| 参考文献： | 1. Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50. 2. Huang D, et al. PPAR-α Agonist WY-14643 Inhibits LPS-Induced Inflammation in Synovial Fibroblasts via NF-kB Pathway. J Mol Neurosci. 2016 Aug;59(4):544-53. 3. Pantazi E, et al. PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury. Biomed Res Int. 2015;2015:894679. | ||||||||||||||||||||
| 溶解性： | DMSO : 100 mg/mL (308.83 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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