| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81748-1mg |
99.8% | ￥305.00 | >10 | - | - | - |
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S81748-5mg |
99.8% | ￥920.00 | >10 | - | - | - |
|
S81748-10mg |
99.8% | ￥1200.00 | >10 | - | - | - |
|
S81748-50mg |
99.8% | ￥4900.00 | >10 | - | - | - |
|
A939572 是一种有效的、口服生物可利用的 stearoyl-CoA desaturase1 (SCD1) 的抑制剂，对 mSCD1 和 hSCD1 的 IC50值分别为 <4 nM 和 37 nM
| 产品描述： | A939572 是一种有效的、口服生物可利用的 stearoyl-CoA desaturase1 (SCD1) 的抑制剂，对 mSCD1 和 hSCD1 的 IC50值分别为 <4 nM 和 37 nM | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | mSCD1(Cell-free assay):4 nM; hSCD1(Cell-free assay):37 nM;Dehydrogenase; Stearoyl-CoADesaturase(SCD) | ||||||||||||||||||||
| 体外研究： | A939572 demonstrates a significant dose-dependent decrease in proliferation in Caki1, A498, Caki2, and ACHN at day 5. In congruity with previous experimentation examining SCD1 lentiviral knockdown models, A939572 induces apoptosis confirmed by PARP cleavage via western blot analysis in all four cell lines. Treatment of ccRCC cells with A939572 induces Endoplasmic Reticulum Stress | ||||||||||||||||||||
| 体内研究： | When compared to the placebo control, all treatment groups (A939572, Tem, and Combo) exhibits decreased proliferation as marked by reduction in percent positivity of nuclear Ki67 staining, with the combinatorial group demonstrating the most significant decline. Combinatorial application of A939572 with temsirolimus synergistically inhibits tumor growth in vivo | ||||||||||||||||||||
| 细胞实验： | Cell lines: Caki1, A498, Caki2, ACHN ccRCC cells Concentrations: 75 nM Incubation Time: 24 h Method: In order to determine the mechanism of decreased proliferation and induction of cell death associated with loss of SCD1 activity in ccRCC cells, gene array analysis was performed with Caki1, A498, Caki2, and ACHN ccRCC cells treated for 24 hours with a 75nM dose of A939572 compared to DMSO control. | ||||||||||||||||||||
| 动物实验： | Animal Models: athymic nu/nu mice Dosages: 30 mg/kg Administration: Oral gavage | ||||||||||||||||||||
| 参考文献： | 1. Zhili Xin, et al. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4298-302. 2. Christina A von Roemeling, et al. Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res. 2013 May 1;19(9):2368-80. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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