货号	规格	价格	上海	北京	珠海	重庆	武汉
S82213-5mg买3赠1	99.90%	￥330.00 S82213-5mg ￥330.00 现货（买3赠1）	7 7	-	-	-	-
S82213-10mg买3赠1	99.90%	￥480.00 S82213-10mg ￥480.00 现货（买3赠1）	6 6	-	-	-	-
S82213-25mg买3赠1	99.90%	￥990.00 S82213-25mg ￥990.00 现货（买3赠1）	5 5	-	-	-	-
S82213-50mg买3赠1	≥99%	￥1590.00 S82213-50mg ￥1590.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis.

靶点：

iGluR;NMDAR; iGluR

体外研究：

ZL006 presents little cytotoxicity, and a growth inhibition of BCECs is not found at low concentration of 0.001, 0.01, 0.1, 1 and 10 μg/mL. The cytotoxicity of T7-P-LPs/ZL006 is significantly enhanced at the concentration of 10 μg/mL. Cellular uptake of ZL006 loads P-LPs and T7-P-LPs after incubation for 0.5 h at the concentrations range from 100 μg/mL to 600 μg/mL in BCECs. ZL006 does not inhibit the nNOS-PDZ/PSD-95-PDZ interaction, or perturb the nNOS β-finger

体内研究：

Compared with P-LPs/ZL006 and free ZL006, T7-P-LPs/ZL006 exhibits a significant increase of drug accumulation in the brain tissue due to its better brain targeting delivery. Compared with free ZL006, P-LPs/ZL006 and T7-P-LPs/ZL006 exhibit a significant decrease of drug accumulation in the liver and kidney

参考文献：

1. Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015 Jul 29;5:12651. 2. Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.047 ml	15.237 ml	30.474 ml
5 mM	0.609 ml	3.047 ml	6.095 ml
10 mM	0.305 ml	1.524 ml	3.047 ml
50 mM	0.061 ml	0.305 ml	0.609 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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