| 产品描述： | (R,R)-BD-AcAc 2 ((R,R)-Ketone Ester), a ketone monoester, can be used as a source of oral nutritional ketones. (R,R)-BD-AcAc 2 can elevate plasma levels of β-hydroxybutyrate and acetoacetate, blood glucose, blood Na+ levels and blood creatinine levels after oral administration in mice. (R,R)-BD-AcAc 2 can partly prevent muscle weakness in septic mice. (R,R)-BD-AcAc 2 has potential to improve exercise performance and endurance in animal body. (R,R)-BD-AcAc 2 can also be used to research Parkinson’s disease or diabetes |
| 靶点： |
ReactiveOxygenSpecies |
| 体内研究： |
(R,R)-BD-AcAc 2 (D-3HHB) increases specific muscle force, moderately raises blood glucose concentrations, lowers Aldh3b2 gene expression, increases blood Na+ levels and blood creatinine levels, and reduces plasma free fatty acid concentrations. Animal Model: Septic mice Dosage: 10, 20, 40 and 80 mmol/kg/day Administration: PO Result: Increased specific muscle force as compared with placebo to 93% of healthy control levels at 40 mmol/kg/day.Resulted in moderately higher blood glucose concentrations as compared with placebo at 40 mmol/kg/day.Lowered Aldh3b2 gene expression than with placebo at 40 mmol/kg/day.Evoked a moderate further increase in blood Na+ levels and increased blood creatinine levels at 20 mmol/kg/day.Reduced plasma free fatty acid concentrations by 10 or 20 mmol/kg/day.Hepatic gene expression levels of Aldh1a7 was also reduced by sepsis but increased by D-3HHB. |
| 参考文献： |
1. Weckx R, et al. Efficacy and safety of ketone ester infusion to prevent muscle weakness in a mouse model of sepsis-induced critical illness. Sci Rep. 2022 Jun 22;12(1):10591. 2. Williams MS, et al. The Chemistry of the Ketogenic Diet: Updates and Opportunities in Organic Synthesis. Int J Mol Sci. 2021 May 15;22(10):5230. 3. Clarke K, et al. Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate. Regul Toxicol Pharmacol. 2012 Jul;63(2):196-208. |
| 溶解性： |
Soluble in DMSO、H2O |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
5.675 ml |
28.375 ml |
56.75 ml |
| 5 mM |
1.135 ml |
5.675 ml |
11.35 ml |
| 10 mM |
0.568 ml |
2.838 ml |
5.675 ml |
| 50 mM |
0.114 ml |
0.568 ml |
1.135 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京